Consumption of Sweet Foods and Tantrums: Can Biochemical Mechanisms Explain Emotional Dysregulation in Toddlers?

Authors

  • Ibnul Mubarok Universitas Trunodjoyo Madura Author https://orcid.org/0009-0005-5085-2804
  • Emeiliya Sufiani Universitas Trunodjoyo Madura Author
  • Miftahul Jannah Universitas Trunodjoyo Madura Author
  • Jamila Jamila Universitas Trunodjoyo Madura Author
  • Dista Amalia Fransischa Universitas Trunodjoyo Madura Author
  • Aditya Rakhmawan Universitas Trunodjoyo Madura Author

DOI:

https://doi.org/10.63822/0ytye093

Keywords:

Toddlers, Emotional dysregulation, Sugar, Biochemical, Temper tantrum

Abstract

Temper tantrums in toddlers are generally explained by psychological factors, while the role of biochemical mechanisms has not yet been extensively studied. This study aims to analyze the biochemical mechanisms underlying the relationship between the consumption of sugary foods and emotional dysregulation in toddlers. The study employed a qualitative descriptive approach through a literature review, analyzing scientific articles and reputable references on glucose metabolism, neurotransmitters, neurobiology, and emotional regulation. The analysis was conducted using content analysis to develop a conceptual synthesis of sucrose digestion, insulin regulation, adenosine triphosphate (ATP) production, dopamine and serotonin synthesis, and changes in gene expression through epigenetic mechanisms. The results of the study indicate that excessive sugar consumption has the potential to trigger fluctuations in blood glucose that disrupt neuronal energy homeostasis and neurotransmitter balance, thereby increasing susceptibility to emotional dysregulation. However, this relationship cannot yet be deemed causal, as it is also influenced by psychological and environmental factors. These findings underscore the importance of a multidisciplinary approach to understanding tantrums in toddlers and provide a foundation for future experimental research.

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Author Biographies

  • Ibnul Mubarok, Universitas Trunodjoyo Madura

    Department of Natural Science Education

  • Emeiliya Sufiani, Universitas Trunodjoyo Madura

    Department of Natural Science Education

  • Miftahul Jannah, Universitas Trunodjoyo Madura

    Department of Natural Science Education

  • Jamila Jamila, Universitas Trunodjoyo Madura

    Department of Natural Science Education

  • Dista Amalia Fransischa, Universitas Trunodjoyo Madura

    Department of Natural Science Education

  • Aditya Rakhmawan, Universitas Trunodjoyo Madura

    Department of Natural Science Education

References

Agustini, D. (2025). Manajemen Tantrum Seumur Hidup: Integrasi Psikologi Modern dan Pendidikan Islam dalam Regulasi Emosi Anak hingga Dewasa. Lisyabab: Jurnal Studi Islam Dan Sosial, 6(1), 125–143. https://doi.org/10.58326/jurnallisyabab.v6i1.389

Altuntaş, Y. (2019). Postprandial reactive hypoglycemia. The Medical Bulletin of Şişli Etfal Hospital, 53(3), 215–220. https://doi.org/10.14744/SEMB.2019.59455

Arshad, M. T., Maqsood, S., Altalhi, R., Shamlan, G., Mohamed Ahmed, I. A., Ikram, A., & Abdullahi, M. A. (2025). Role of dietary carbohydrates in cognitive function: A review. Food Science & Nutrition. 13(7), e70516. https://doi.org/10.1002/fsn3.70516

Attwell, D., & Laughlin, S. B. (2001). An energy budget for signaling in the grey matter of the brain. Journal of Cerebral Blood Flow & Metabolism, 21(10), 1133–1145. https://doi.org/10.1097/00004647-200110000-00001

Björklund, A., & Dunnett, S. B. (2022). Dopamine neuron systems in the brain: An update. Trends in Neurosciences, 45(3), 194–205. https://doi.org/10.1016/j.tins.2021.11.003

Cryer, P. E. (2021). Hypoglycemia-associated autonomic failure in diabetes: Maladaptive, adaptive, or both?. Diabetes, 70(5), 1111–1118. https://doi.org/10.2337/dbi20-0056

Blum, K., Bowirrat, A., Baron, D., Elman, I., Makale, M. T., Cadet, J. L., Thanos, P. K., Hanna, C., Ahmed, R., Gondre-Lewis, M. C., Dennen, C. A., Braverman, E. R., Soni, D., Carney, P., Khalsa, J., Modestino, E. J., Barh, D., Bagchi, D., Badgaiyan, R. D., McLaughlin, T., … Gold, M. S. (2024). Identification of stress-induced epigenetic methylation onto dopamine D2 gene and neurological and behavioral consequences. Gene & Protein in Disease. 3(1), 10.36922/gpd.1966. https://doi.org/10.36922/gpd.1966

Cahyono, A. D. (2021). Peranan Pengembangan Manajemen Kinerja Tenaga Administrasi Kesehatan Terhadap Peningkatan Mutu Pelayanan Kesehatan di Puskesmas. Jurnal Ilmiah Pamenang, 3(2), 28–42. https://doi.org/10.53599/jip.v3i2.81

Datta, D., & Arnsten, A. F. T. (2019). Loss of Prefrontal Cortical Higher Cognition with Uncontrollable Stress: Molecular Mechanisms, Changes with Age, and Relevance to Treatment. Brain Sciences, 9(5), 113. https://doi.org/10.3390/brainsci9050113

Daubner, S. C., Le, T., & Wang, S. (2011). Tyrosine hydroxylase and regulation of dopamine synthesis. Archives of Biochemistry and Biophysics. 508(1), 1–12. https://doi.org/10.1016/j.abb.2010.12.017

Del-Ponte, B., Anselmi, L., Assunção, M. C. F., Tovo-Rodrigues, L., Munhoz, T. N., Matijasevich, A., Rohde, L. A., & Santos, I. S. (2019). Sugar consumption and attention-deficit/hyperactivity disorder (ADHD): A birth cohort study. Journal of Affective Disorders, 243, 290–296. https://doi.org/10.1016/j.jad.2018.09.051

Dienel, G. A. (2019). Brain glucose metabolism: Integration of energetics with function. Physiological Reviews. 99(1), 949–1045. https://doi.org/10.1152/physrev.00062.2017

Fernstrom, J. D. (2013). Large neutral amino acids: Dietary effects on brain neurochemistry and function. Amino Acids, 45(3), 419–430. https://doi.org/10.1007/s00726-012-1330-y

Ferraris, R. P., & de Oliveira, M. A. (2023). Intestinal absorption of carbohydrates and sugars. Comprehensive Physiology. https://doi.org/10.1002/cphy.c220013

Gee, D. G. (2016). The neurodevelopment of emotion regulation: A pathway to risk and resilience. Current Opinion in Behavioral Sciences, 10, 22–29. https://doi.org/10.1016/j.cobeha.2016.05.007

Gericke, B., Amiri, M., & Naim, H. Y. (2016). The multiple roles of sucrase-isomaltase in the intestinal physiology. Molecular and Cellular Pediatrics. 3(2). https://doi.org/10.1186/s40348-016-0033-y

He, Y., Xie, K., Yang, K., Wang, N., & Zhang, L. (2025). Unraveling the Interplay Between Metabolism and Neurodevelopment in Health and Disease. CNS Neuroscience & Therapeutics, 31(5), e70427. https://doi.org/10.1111/cns.70427

Karimanudin, I. R., Nursetyanti, R. I., Zahrotunnisa, N. A., Nikmah, F., & Safari, D. S. (2025). Dampak Konsumsi Makanan Tinggi Gula Terhadap Perubahan Mood Pada GenZ. Jurnal Ilmu Psikologi Dan Kesehatan, 2(3), 104–110. https://jurnal.kopusindo.com/index.php/jipk/article/view/1354

Kwan, T. N., Marhoon, N., Young, M., Holmes, N., & Bellomo, R. (2022). Insulin therapy associated relative hypoglycemia during critical illness. Journal of Critical Care, 70, 154018. https://doi.org/10.1016/j.jcrc.2022.154018

Lailiyah, H. W., Nisa, Z., & Nisfa, N. L. (2023). Pengaruh Temper Tantrum terhadap Perubahan Perilaku dan Psikis pada Anak Usia Dini. Juraliansi: Jurnal Lingkup Anak Usia Dini, 4(1), 61–69. https://doi.org/10.35897/juraliansi.v4i1.849

Lestari, W. A., Putri, C. E., Sugiarti, R., & Suhariadi, F. (2021). Pengelolaan Perilaku Tantrum oleh Ibu terhadap Anak Usia 12-48 Bulan. Proyeksi: Jurnal Psikologi, 16(2), 208–219. https://doi.org/10.30659/jp.16.2.208-219

Liu, W. W., & Bohórquez, D. V. (2022). The neural basis of sugar preference. Nature Reviews Neuroscience, 23(10), 584–595. https://doi.org/10.1038/s41583-022-00613-5

Llauradó-Pont, J., et al., (2025). A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children. Clinical Epigenetics.17 (3). https://doi.org/10.1186/s13148-024-01782-z

Myers, M. G., Jr., Affinati, A. H., Richardson, N., & Schwartz, M. W. (2021). Central nervous system regulation of organismal energy and glucose homeostasis. Nature Metabolism, 3(6), 737–750. https://doi.org/10.1038/s42255-021-00408-5

Novitasari, N., Sibualamu, K. Z., & Saragih, D. B. (2025). Hubungan Antara Konsumsi Makanan Manis Dan Regulasi Emosi Anak Prasekolah. Jurnal Asuhan Ibu Dan Anak, 10(2), 113–123. https://doi.org/10.33867/jqapkx95

Patel, P., Selvaraju, V., Babu, J. R., & Geetha, T. (2023). Association of the DNA methylation of obesity-related genes with the dietary nutrient intake in children. Nutrients. 15(13), 2840. https://doi.org/10.3390/nu15132840

Paulus, F. W., Ohmann, S., Möhler, E., Plener, P., & Popow, C. (2021). Emotional Dysregulation in Children and Adolescents With Psychiatric Disorders. A Narrative Review. Frontiers in Psychiatry, 12, 628252. https://doi.org/10.3389/fpsyt.2021

Peng, W., Tan, C., Mo, L., Jiang, J., Zhou, W., Du, J., Zhou, X., Liu, X., & Chen, L. (2021). Glucose transporter 3 in neuronal glucose metabolism: Health and diseases. Metabolism, 123, Article 154869. https://doi.org/10.1016/j.metabol.2021. 154869

Petersen, M. C., & Shulman, G. I. (2022). Mechanisms of insulin action and insulin resistance. Physiological Reviews, 98(4), 2133–2223. https://doi.org/10.1152/physrev.00063 .2017

Qin, D., Qi, J., Shi, F., Guo, Z., & Li, H. (2025). About sugar addiction. Brain and Behavior. 15(7), e70338. https://doi.org/10.1002/brb3.70338

Ren, J., Isakova, A., Friedmann, D., et al. (2024). The molecular and cellular organization of the brain serotonergic system. Cell, 187(5), 1155–1174.e34. https://doi.org/10.1016/j.cell.2024.01.019

Roberts, D. J., & Miyamoto, S. (2014). Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy. Cell Death & Differentiation. 22(2), 248–257. https://doi.org/10.1038/cdd.2014.173

Scherer, T., Sakamoto, K., & Buettner, C. (2021). Brain insulin signalling in metabolic homeostasis and disease. Nature Reviews Endocrinology, 17(8), 468–483. https://doi.org/10.1038/s41574-021-00498-x

Subagja, R. A., & Catya, K. (2024). Perancangan Motion Explainer Dampak Gejala Tantrum bagi Kesehatan Mental Anak Umur 3-5 Tahun di Kota Surabaya. Jurnal Barik, 6(1), 100–114. https://doi.org/10.26740/jdkv.v6i1. 62123

Zhang, Y., Hort, J., & Taylor, A. J. (2022). The starch hydrolysis and aroma retention caused by salivary α-amylase during oral processing of food. Current Opinion in Food Science, 43, 237–245. https://doi.org/10.1016/j.cofs.2021.11.014

Zou, X. H., Sun, L. H., Yang, W., Li, B. J., & Cui, R. J. (2020). Potential Role of Insulin on the Pathogenesis of Depression. Cell Proliferation, 53(5), e12806. https://doi.org/10.1111/cpr.12806

Published

2026-07-08

How to Cite

Mubarok, I., Sufiani, E. ., Jannah, M., Jamila, J., Amalia, D. ., & Rakhmawan, A. (2026). Consumption of Sweet Foods and Tantrums: Can Biochemical Mechanisms Explain Emotional Dysregulation in Toddlers?. Journal of Literature Review, 2(2), 693-701. https://doi.org/10.63822/0ytye093